We present the case of a 64-year-old female patient with a history of colostomy due to low rectal neoplasia with a mixed nodular lesion (LST-GM) located in the ascending colon of about 50 mm that is resected with classical dissection technique (classic ESD) within of the course «Current management of early neoplasms of the colon» by Dr. Rosón and Dr. Gallardo. Orise gel from Boston Scientific was used as a submucosal solution. Flush-Knife BT 1.5 mm and Fujifilm EC-740TM colonoscope as endoknive an scope. Olympus ESG-300 as elctrosurgical unit.